HelpNDoc exclusively runs on Windows operating systems. Recommended system requirements are:
- Windows Vista, Windows 7, Windows 8 or Windows 10
- 512MB of RAM
- 80MB of free disk space
- 1024x768 screen resolution or higher
- Microsoft HTML Help Workshop is required to compile CHM help files
- Amazon KindleGen is required to compile Kindle compatible eBooks
- The Qt Framework is required to compile Qt Help files